Windows shuts down unused spinning hard disks after 20 minutes by default, to minimize power consumption.
So, not much gained by un-plugging. Except more safety, in case your PC becomes infected by disk encryption malware.
Also to consider (from Wikipedia:
https://en.wikipedia.org/wiki/USB_hardware):
Standard USB has a minimum rated lifetime of 1,500 cycles of insertion and removal, the mini-USB receptacle increases this to 5,000 cycles, and the newer Micro-USB and USB-C receptacles are both designed for a minimum rated lifetime of 10,000 cycles of insertion and removal.Assuming you unplug the computer-facing plug and it plugs into a standard (big A type) USB plug, you have 1,500 plug-in/pull cycles before (in theory) the receptacle kicks it.
1,500 cycles means that when you plug/unplug once a day, the receptacle or plug will last about 4 years.
For safety, assume a lifespan of 3 years for an external disk. Many live a lot longer, but if the data on the disk is important, replace disks every 3 years (and always have a full and up-to-date backup of course).
To reduce the wear on the USB receptacle in your PC, always unplug on the disk side. If you replace the disk (with enclosure) every 3 years, you get a new USB receptacle when you replace the disk.